Synthesis of potentially bioactive PABA-related N -(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions
Identifieur interne : 000F27 ( Main/Exploration ); précédent : 000F26; suivant : 000F28Synthesis of potentially bioactive PABA-related N -(aminoalkyl)lactamic amino acids and esters via selective SNAr reactions
Auteurs : Renato S. Gonçalves [Brésil] ; Patrícia V. Abdelnur [Brésil] ; Vanessa G. Santos [Brésil] ; Rosineide C. Simas [Brésil] ; Marcos N. Eberlin [Brésil] ; Alviclér Magalhães [Brésil] ; Eduardo R. Pérez González [Brésil]Source :
- Amino Acids [ 0939-4451 ] ; 2011-01-01.
English descriptors
Abstract
Abstract: Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by SNAr reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition–elimination SNAr mechanism was confirmed by NMR and MS measurements. Graphical Abstract:
Url:
DOI: 10.1007/s00726-010-0634-z
Affiliations:
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Pérez González</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Química Orgânica Fina, Departamento de Física, Química e Biologia, Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista, Campus de Presidente Prudente, C.P. 467, 19060-900, Presidente Prudente, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Brésil</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Amino Acids</title><title level="j" type="sub">The Forum for Amino Acid, Peptide and Protein Research</title><title level="j" type="abbrev">Amino Acids</title><idno type="ISSN">0939-4451</idno><idno type="eISSN">1438-2199</idno><imprint><publisher>Springer Vienna</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2011-01-01">2011-01-01</date><biblScope unit="volume">40</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="197">197</biblScope><biblScope unit="page" to="204">204</biblScope></imprint><idno type="ISSN">0939-4451</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0939-4451</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lactams</term><term>PABA derivatives</term><term>Potential bio-activity</term><term>SNAr reaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Potentially bioactive N-(aminoalkyl)lactamic amino acids and esters were synthesized in satisfactory to good yields by SNAr reactions of aromatic acids with N-(3-aminopropyl)lactams followed by esterification with tertiary amino alcohols. The addition–elimination SNAr mechanism was confirmed by NMR and MS measurements. Graphical Abstract:</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Goncalves, Renato S" sort="Goncalves, Renato S" uniqKey="Goncalves R" first="Renato S." last="Gonçalves">Renato S. Gonçalves</name></region><name sortKey="Abdelnur, Patricia V" sort="Abdelnur, Patricia V" uniqKey="Abdelnur P" first="Patrícia V." last="Abdelnur">Patrícia V. Abdelnur</name><name sortKey="Eberlin, Marcos N" sort="Eberlin, Marcos N" uniqKey="Eberlin M" first="Marcos N." last="Eberlin">Marcos N. Eberlin</name><name sortKey="Goncalves, Renato S" sort="Goncalves, Renato S" uniqKey="Goncalves R" first="Renato S." last="Gonçalves">Renato S. Gonçalves</name><name sortKey="Magalhaes, Alvicler" sort="Magalhaes, Alvicler" uniqKey="Magalhaes A" first="Alviclér" last="Magalhães">Alviclér Magalhães</name><name sortKey="Perez Gonzalez, Eduardo R" sort="Perez Gonzalez, Eduardo R" uniqKey="Perez Gonzalez E" first="Eduardo R." last="Pérez González">Eduardo R. Pérez González</name><name sortKey="Perez Gonzalez, Eduardo R" sort="Perez Gonzalez, Eduardo R" uniqKey="Perez Gonzalez E" first="Eduardo R." last="Pérez González">Eduardo R. Pérez González</name><name sortKey="Santos, Vanessa G" sort="Santos, Vanessa G" uniqKey="Santos V" first="Vanessa G." last="Santos">Vanessa G. Santos</name><name sortKey="Simas, Rosineide C" sort="Simas, Rosineide C" uniqKey="Simas R" first="Rosineide C." last="Simas">Rosineide C. Simas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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